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Pemberton's sign
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Pemberton's sign : ウィキペディア英語版
Pemberton's sign
Pemberton's sign was named after Dr. Hugh Pemberton, who characterized it in 1946.
The Pemberton maneuver is a physical examination tool used to demonstrate the presence of latent pressure in the thoracic inlet. The maneuver is achieved by having the patient elevate both arms until they touch the sides of the face. A positive Pemberton's sign is marked by the presence of facial congestion and cyanosis, as well as respiratory distress after approximately one minute.
==Causes==
A positive Pemberton's sign is indicative of superior vena cava syndrome (SVC), commonly the result of a mass in the mediastinum. Although the sign is most commonly described in patients with substernal goiters where the goiter “corks off” the thoracic inlet, the maneuver is potentially useful in any patient with adenopathy, tumor, or fibrosis involving the mediastinum. SVC has been observed as a result of diffuse mediastinal lymphadenopathy of various pathologies such as cystic fibrosis and Castleman’s disease. Park ''et al.'' reported enlarged cervical lymph nodes associated with hemophagocytic lymphohistiocytosis as the cause of internal jugular vein compression, which presented clinically similar to SVC syndrome. More recently, Tipton ''et al.'' described a patient with diffuse mediastinal lymphadenopathy due to amyloidosis. The unique configuration of enlarged lymph nodes resulted in a positive Pemberton's Sign. Not surprisingly, apical lung cancers may cause a positive Pemberton's sign and a high index of suspicion should be maintained in patients with symptoms of dyspnea and facial plethora with an extensive smoking history.

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